Health & Fit Synthetic opioids even more deadly, CDC says

17:59  12 july  2018
17:59  12 july  2018 Source:   nbcnews.com

This engineered painkiller works like an opioid but isn't addictive in animal tests

  This engineered painkiller works like an opioid but isn't addictive in animal tests <p>What if there were a drug that did the job opioids do best - relieve pain - without prompting many of their negative side effects.</p>Addiction, of course, is a particularly dangerous and disruptive side effect, since it hijacks a patient's brain and demands escalating doses of opioid drugs to hold withdrawal symptoms at bay.

Deaths from these drugs nearly doubled from 2016 to 2017, the CDC said . Other illicit synthetic opioids include furanylfentanyl and acrylfentanyl. Large U.S. cities see big jump in deadly opioid overdoses, CDC data shows. “Ohio alone reported more than 1,700 opioid overdose deaths testing

The first wave began with increased prescribing of opioids in the 1990s 2, with overdose deaths involving prescription opioids (natural and semi- synthetic opioids and methadone) increasing since at least 1999. Read more about CDC ’s role in the opioid overdose epidemic.

Image: embers of the Hazmat unit respond to the scene of an overdose that killed two peopleMembers of a hazmat team at the scene of a suspected carfentanil overdose that killed two people in Lawrence, Massachusetts, on July 17, 2017. Authorities alerted the team because exposure to even a small amount of carfentanil can cause serious injury or death. © Provided by NBCU News Group, a division of NBCUniversal Media LLC Image: embers of the Hazmat unit respond to the scene of an overdose that killed two peopleMembers of a hazmat team at the scene of a suspected carfentanil overdose that killed two people in Lawrence, Massachusetts, on July 17, 2017. Authorities alerted the team because exposure to even a small amount of carfentanil can cause serious injury or death. Overdose victims may need extra naloxone, the agency warns.

New synthetic opioids are killing more people than ever before, with more than half of all opioid overdose deaths caused by the powerful, lab-made drugs, federal officials said Wednesday.

Walmart to limit opioid prescriptions at pharmacies amid epidemic

  Walmart to limit opioid prescriptions at pharmacies amid epidemic Walmart Inc. announced Monday the retail giant will begin to restrict opioid prescriptions in an effort to help stem the deadly drug epidemic. Walmart announced Monday the retail giant will begin to restrict opioid prescriptions to help Walmart and Sam’s Club pharmacies are set to limit customers’ opioid prescriptions to a seven-day supply, with up to a 50 morphine milligram equivalent maximum per day, the company said in a news release.

A new report from the Centers for Disease Control and Prevention says opioids are a factor in That’s how much the death rate due to synthetic opioids increased among Latinos and Asians and The number of "waves" in the epidemic of opioid overdose deaths, according to the CDC researchers.

“No area of the United States is exempt from this epidemic—we all know a friend, family member, or loved one devastated by opioids ,” said CDC The overdose death rate from synthetic opioids (other than methadone) more than doubled, likely driven by illicitly manufactured fentanyl (IMF).

The Centers for Disease Control and Prevention issued a Health Alert Network warning about the increased supply of the illicit drugs, which are many times stronger than fentanyl, the prescription painkiller.

"The dramatic rise in the supply of illicitly manufactured fentanyl and fentanyl analogs has been mirrored by an equally dramatic rise in deaths involving synthetic opioids other than methadone, a category which includes fentanyl and fentanyl analogs," the CDC said in its alert.

Death rates doubled between 2015 and 2016, the CDC said. "More than 55 percent of opioid overdose deaths occurring nationally in the 12 months ending November 2017 involved synthetic opioids, accounting for more than 27,000 overdose deaths," the CDC said in the health alert, citing preliminary numbers.

FDA Approves Lucemyra For Treating Opioid Withdrawal Symptoms

  FDA Approves Lucemyra For Treating Opioid Withdrawal Symptoms Lucemyra has been approved for easing the severity of opioid withdrawal symptoms in adults, stated a press release from the Food and Drug Administration.The United States Food and Drug Administration (FDA) has approved a nonopioid drug called Lucemyra for the treatment of opioid withdrawal symptoms in adults. Developing safe and effective treatments for opioid use disorder remained a major priority for the agency, stated a press announcement released on May 16.

Consider CDC ’s opioid prescribing guideline for chronic pain, which helps primary care providers offer safer, more effective care. MMWR: Trends in deaths involving heroin and synthetic opioids excluding methadone and drug product reports by U.S. Census region, United States — 2006–2015.

According to the CDC , much of the increase in fatal opioid overdoses was driven by the rise in illegal synthetic opioids other than methadone, such as fentanyl and “This means that even if you ignored deaths from all other drugs, the opioid epidemic alone is deadlier than the AIDS epidemic at its peak.”

That's up from 20,000 overdose deaths from synthetic opioids in 2016.

People who overdose on the synthetics may need multiple doses of naloxone, the drug that can reverse an overdose, the CDC added.

The new drugs include carfentanil, which is 100 times more potent than fentanyl, the CDC said. Another is 3-methylfentanyl, which is four times as powerful. Deaths from these drugs nearly doubled from 2016 to 2017, the CDC said.

Other illicit synthetic opioids include furanylfentanyl and acrylfentanyl. "Finally, drug submissions testing positive for a synthetic illicit opioid known as U-47700, first encountered by the DEA in 2016, increased from 533 submissions in 2016 to 1,087 during January-June, 2017," the CDC said in the alert, referring to the Drug Enforcement Administration.

Some of the new drugs may not be detected by standard tests, and coroners and medical examiners may need to use a mass spectrometer to detect the substances.

Deaths from fentanyl surge to record 746 in California

  Deaths from fentanyl surge to record 746 in California According to the California Department of Public Health, 746 people died from fentanyl overdoses last year. That is more than three times the 237 people who died from fentanyl overdoses in 2016, and nine times the 81 who died from overdosing on the drug in 2013.&nbsp;According to the California Department of Public Health, 746 people died from fentanyl overdoses last year. That is more than three times the 237 people who died from fentanyl overdoses in 2016, and nine times the 81 who died from overdosing on the drug in 2013.

Death rates from synthetic opioids , including fentanyl, increased 72.2% from 2014 to 2015, the US Centers for Disease Control and Prevention said Friday. There were more than 33,000 opioid deaths in 2015, the CDC says .

One of the most dangerous drugs is a synthetic opioid ‘so potent and that even a microgram “It is so potent and so deadly that even a microgram amount can kill someone,” said Drug Meanwhile in Ohio there were 1,245 fentanyl seizures in 2014, the most of any state according to the CDC .

And they're often being used to cut other drugs, such as cocaine, the CDC said.

The U.S. is suffering through a terrible epidemic of opioid abuse. Opioids, including prescription opioids and heroin, killed 42,000 people in 2016, the CDC says. Opioid overdose deaths are so bad that they have helped drive down U.S. life expectancy.

Starting in 2016, most deaths were caused by the street synthetics. That continued into 2017, the CDC said. "This 12-month sum of synthetic opioid overdose deaths exceeds the total number of all opioid overdose deaths in 2013, when deaths involving synthetic opioids first began to climb," the CDC said.

"Ohio alone reported more than 1,700 opioid overdose deaths testing positive for fentanyl analogs during July 2016-June 2017, with more than 1,100 of those deaths involving carfentanil."

Emergency responders and physicians may not know that people overdosing on the synthetics may need extra care, the CDC said.

"Orally ingested counterfeit pills laced with fentanyl or fentanyl analogs may require prolonged dosing of naloxone in the ED hospital setting due to a delayed toxicity that has been reported in some cases," the CDC said

Pain sufferers beg FDA for more options .
People with chronic conditions cope with prescription restrictions and limited alternative therapies SILVER SPRING, Maryland — One pain patient lay on the floor. Another leaned against the wall, easing her back. A third paced to and fro.At this week's Food and Drug Administration hearing on chronic pain, accommodations were at the forefront.And the agency says it wants to be accommodating in other ways as it tackles the opioid crisis. Thus, a meeting was called simply to listen to people's stories about their pain and how they may, or may not, handle it.It was a room full of some very unhappy people.

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