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US Fertility clinic failure worse than thought

17:10  27 march  2018
17:10  27 march  2018 Source:   nbcnews.com

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Equipment failures on the same day at two fertility clinics located across the country from each other—in California and Ohio—may have damaged or destroyed thousands of frozen eggs and embryos.

More than three weeks after a tank failure at a fertility center in Cleveland, the University Hospitals Fertility Center is now saying 4,000 frozen eggs and embryos were lost — twice the number the hospital initially reported.

Nearly 1,000 patients of the University Hospitals Fertility Center are being sent letters apologizing once more and acknowledging some of the reasons a storage tank failed. The hospital is now blaming human error for the loss of those frozen eggs and embryos, some of which had been stored for decades.

At the same time, NBC News has uncovered a history of malfunctions in other tanks from the same manufacturer.

In crushing news for the affected patients, it's unlikely, the hospital says in its new letter, that any of the stored eggs and embryos are viable.

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2nd fertility clinic reports equipment failure , hu CBS Evening News. We need to think : If this tissue doesn't work, what are the next steps, and have you not feel defeated." It's the second such failure at a U.S. clinic in a matter of days. Last week, an Ohio hospital said more than 2,000 frozen

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In a draft letter detailed to NBC News, University Hospitals Fertility Center says the remote alarm system on the tank — which should have alerted an employee to temperature swings — was shut off. The center does not know who turned it off, but it was off during the weekend of March 3.

Despite 11 miscarriages, Wendy and Rick Penniman had two healthy children with the help of University Hospitals Fertility Center. But now, there's no hope of using their frozen embryos to have a third child.

"It's devastating, I think, for us, but it's more devastating because it's taking something away from our kids," said Wendy Penniman, 41.

Christina and Marc Ellis wanted to use their two remaining embryos at the center to give their daughter, now 2, a sibling.

"I don't know if I can go through the whole process again. And what's the outcome gonna be?" Christina Ellis told NBC News.

Both couples are now suing. So are at least 16 other sets of plaintiffs, all claiming negligence and breach of contract.

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History of malfunctions

And there may be an underlying technical problem — one that's happened before.

An NBC News investigation has found the manufacturer of this particular storage tank, Custom Biogenic Systems, has a history of previous malfunctions dating back almost 15 years.

In 2003, Rachel Southwood's husband Andrew had sperm frozen in the UK after he was diagnosed with cancer. The Tauton, England, couple had one child and hoped they would be able to have another.

"He gave the sample and as far as we were aware, we would potentially be able to have more children," Southwood said.

But less than a year later, the freezer storing his sperm malfunctioned, rendering the sperm no longer viable. Andrew Southwood eventually died from cancer.

"They simply said that there had been a technical malfunction with the unit that was storing the sperm of my husband," said Southwood, who was 30 when the malfunction occurred.

In 2003, British regulators warned that freezers made by CBS, a Michigan company, had problems with their automatic filling mechanisms.

More than 4,000 eggs and embryos lost in Cleveland fertility clinic tank failure

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Now, hundreds of these women and couples have learned that the eggs and embryos they froze for eventual use in starting or expanding a family may have been destroyed by storage tank failures March 4 at two fertility clinics in suburban Cleveland and San Francisco.

CLEVELAND (AP) — The Latest on the equipment failures at fertility clinics in California and Ohio (all times Eastern): 2:45 p.m. But he says that so far, nobody knows of any connection between the two failures . He says it's "just a bad , bad , bad coincidence."

"The manufacturer is aware of 21 incidents" in the UK, regulators said.

"The alert was withdrawn," according to a statement from the UK's Medicines and Healthcare Products Regulatory Agency to NBC News. "The UK supplier informed MHRA that 95% of the devices in the UK had been returned and upgraded. The other 5% were to be complete by 2006. Therefore, this issue should no longer be affecting the UK. No further reports have been received by MHRA since September 2005."

But two years later, after the warning was first issued, a similar incident occurred in Gainesville, Florida. Up to 60 male patients, many with cancer, lost stored sperm when a tank made by the same manufacturer failed.

Experts estimate that there are around 500 clinics that specialize in assisted reproduction around the country, based on a 2015 report about the state of assisted reproduction by the Centers for Disease Control and Prevention. That report included a list of 451 clinics that have provided them with data and 35 others that had not.

'Almost no regulation'

The lack of reliable data on procedures and clinics in the United States — and possible problems with their frozen eggs and embryos — has contributed to a "regulatory vacuum," says Dov Fox, director of the Center for Health Law Policy and Bioethics at the University of San Diego.

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CLEVELAND (AP) — The Latest on the equipment failures at fertility clinics in California and Ohio (all times Eastern): 2:45 p.m. But he says that so far, nobody knows of any connection between the two failures . He says it’s “just a bad , bad , bad coincidence.”

A San Francisco fertility clinic says that a problem with the liquid nitrogen in one of its storage In San Francisco, Dr. Herbert said the clinic is working to determine the effects of the tank failure . We need to think : If this tissue doesn't work, what are the next steps, and have you not feel defeated."

"There is almost no regulation or oversight of any kind that relates directly to the prevention of mistakes like these," said Fox, who is working with one of the plaintiffs in the Cleveland case.

"And it's not just fertility clinics, it's sperm banks, egg vendors, surrogacy agencies, in all these areas, we don't know how common the mistakes are, because there is no reporting, no tracking agencies."

NBC News contacted federal regulatory agencies and organizations that provide accreditation for fertility labs. When NBC News' Investigative Unit asked who's ultimately responsible, most said it wasn't them.

The only government agency that told NBC News it technically could regulate storage tanks is the Food and Drug Administration, or FDA. But because freezers in fertility clinics have not been specifically marketed as medical devices, it doesn't.

Members of the assisted reproduction industry say tank failures like the one in Ohio wouldn't have been prevented with more regulations.

"Autofill tanks still require regular periodic checks by laboratory staff to ensure that they are functioning properly," said Dr. Alan Penzias, a fertility specialist at Boston IVF, an associate professor of obstetrics, gynecology and reproductive biology at Harvard Medical School, and chair of the practices committee at the American Society for Reproductive Medicine, or ASRM.

"I spoke with members of my laboratory staff who informed me that this is common knowledge."

Fear of lawyers may have played a role in stopping wider reporting of previous failures in the US, says Dr. Mark Jutras, lab and medical director at Advanced Reproductive Concepts in Charlotte, NC.

Legal actions grow after loss of frozen embryos

  Legal actions grow after loss of frozen embryos The University Hospitals Fertility Clinic in Cleveland is facing legal action after the failure of a cryopreservation tank containing 4,000 eggs and embryos belonging to at least 950 families. "We currently represent well over 100 clients whose cases we will pursue as individual claims. That number is growing by the day," Cleveland attorney Tom Merriman said Monday. Also Monday, attorney Gloria Allred threw her hat into the ring, announcing litigation on behalf of three Pittsburgh women who are all cancer survivors.

‘Some women may be thinking of trying to get pregnant in six months or a year’s time but finding out whether or not her ovarian reserve (egg store) is low can help that woman make a decision sooner rather than later.’ A fertility test used to mean making an appointment at a private clinic and giving a

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"It is usually institutions who have failures and their lawyers will not allow outside people to analyze the situation to find the root cause of the problem and how it could have been avoided," said Jutras.

That's little comfort for the patients who lost their frozen eggs and embryos at University Hospitals Fertility Center.

"Who else has the tanks," asked Wendy Penniman. "And how many babies are at risk right now while we sit, while we talk?"

The draft University Hospitals letter told patients the facility had obtained another working storage tank and had planned to move frozen eggs and embryos into that extra tank tank and had planned to move frozen eggs and embryos into that extra tank before the weekend of March 3 but hadn't started that process when the failure occurred. The fertility center has offered to pay for treatments for any patients who want them.

The Ellises are considering that. The Pennimans declined the offer.

NBC News repeatedly reached out to the manufacturer CBS and they declined to comment. In a user's manual obtained by the NBC News Medical Unit, the manufacturer devotes a whole page to "Recommended Best Practices in the industry for safe sample storage."

In a section titled, "Why do I need a Secondary or Back-Up Alarm?" the manufacturer also warns, "Your freezer could malfunction. By having a secondary or back-up alarm you can minimize the possibility of a loss due to a malfunction."

Courtney McGee, Jane Weaver, Susan Wagner and contributor Linda Carroll contributed to this NBC News report

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